1 p.m. ET | FOX
Matchup rating: 14.0 | Spread: NYG -5.5 (42.5)
What to watch for: Cincinnati is playing its first game of the season without rookie quarterback Joe Burrow, and the other options on the depth chart -- Ryan Finley and Brandon Allen, who is getting start -- are not nearly as potent as the 2020 top overall draft pick. The Giants are looking to win their third straight game and stay in the mix to win a woeful NFC East. -- Ben Baby
Bold prediction: The Giants will win despite two turnovers from quarterback Daniel Jones. It doesn't matter that they are 0-5 this year when he commits two or more turnovers. This time the Giants are the better team. They will be able to overcome the miscues (coming off two clean games) for the first time this season. -- Jordan Raanan
Stat to know: The Giants are seeking their first three-game winning streak since 2016. They are the only NFL team without a three-game winning streak in past four seasons.
What to know for fantasy: Cincinnati receiver Tee Higgins led the team in targets from Finley last week after the Burrow injury, but it is Tyler Boyd who has more experience with the backup, as he saw 21 targets in three games with Finley last season. See Week 12 rankings.
Betting nugget: The Giants have covered eight straight road games, including all five under coach Joe Judge this season. Read more.
Raanan's pick: Giants 22, Bengals 13
Baby's pick: Giants 24, Bengals 10
FPI prediction: NYG, 54.8% (by an average of 1.7 points)