Deebo Samuel is among the top point-getters at receiver, Sam Darnold looks improved and Devin Singletary has stepped it up a notch.
- 8/14L 19-16
- 8/22W 15-10
- 8/29W 34-10
- 9/12W 41-33
- 9/19W 17-11
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- Full Schedule
The 49ers have already ruled out RB JaMycal Hasty for next week's game against the Packers but said rookies Elijah Mitchell and Trey Sermon have a chance to play.
San Francisco's Elijah Mitchell suffered a right shoulder injury in the 49ers' victory over the Eagles in Philadelphia on Sunday, another in a long line of backfield injuries that have plagued coach Kyle Shanahan's 2-0 club.
— Jimmy Garoppolo wasn't thinking about Trey Lance coming into the game. He was too busy using his own legs to convert first downs.
For the second straight year, the 49ers' stay at the West Virginia-based Greenbrier meant the team was nursing multiple injuries to key players.
Is Nelson Agholor the Patriots' No. 1 wideout? What's the deal with Brandon Aiyuk in San Francisco? Our reporters fill you in before Sunday's games.
Our NFL team reporters round up injury updates for key players in Week 2.
San Francisco 49ers LB Dre Greenlaw will miss extended time because he's slated to have surgery to repair a groin injury, a league source confirmed to ESPN.
No contribution was too small as these first-year QBs begin their promising careers.
San Francisco 49ers running back Raheem Mostert announced Tuesday that he will undergo season-ending knee surgery after consulting with multiple doctors.
DeVonta Smith found the end zone, Mac Jones showed poise for the Pats, and Joe Tryon-Shoyinka made his mark on the veteran Super Bowl champs.
How did the rookie starters look in Week 1? What did Trevor Lawrence, Zach Wilson and Mac Jones do well -- and not so well? Plus, when will Trey Lance and Justin Fields start?
Arizona lit it up on offense, Sam Darnold rolled against his old Jets team and the Bills looked ... off. Here's what to know and what it means going forward for every Week 1 game.
Former San Francisco 49ers linebacker and director of player engagement Parys Haralson, who also played two seasons in New Orleans, died Monday. He was 37.
Niners running back Raheem Mostert is headed to injured reserve and is expected to miss eight weeks with chipped cartilage in a knee, and cornerback Jason Verrett is out for the rest of the season with a torn ACL.
— Nick Bosa was ready to kick back and relax while the San Francisco 49ers coasted to a season-opening victory.
Kyle Shanahan said after his team's victory Sunday that the Niners fear CB Jason Verrett has a torn ACL. RB Raheem Mostert also suffered a knee injury in the victory. Both will undergo more tests
Lance shared snaps with starting quarterback Jimmy Garoppolo in the first quarter of the season opener.
One of the many reasons the 49ers traded up to the third overall spot in this year's NFL draft was the belief that the Patriots could also trade up to No. 3 and beat them to QB Mac Jones, league sources told ESPN.
Teams are making final adjustments to their roster before Week 1, which means managing their injury report.
With their new found freedom to pick new numbers, these digits are the most popular among current NFL players.
Incumbent 49ers QB Jimmy Garoppolo all but confirmed he would start Sunday's opener, and though Kyle Shanahan again declined when asked to name his starter, the coach did say, "I feel like I've already answered it."
Think your favorite team has no shot at a title this season? Think again. Let's count them down, from the worst squad to the best.
NFL execs predict the biggest award winners: Picks for MVP, best rookies, top comeback player, breakouts
Who will win MVP? Who will be the NFL's top rookies? Who is primed for a big breakout? We asked execs, scouts and coaches around the league for their picks.
The 2021 NFL season is nearly here. Our NFL Nation reporters have you covered with intel and projections on all 32 teams.