Joaquin Correa scored early for a depleted Lazio but his side were held to a 1-1 draw by Club Brugge in an entertaining Champions League clash.
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Luis Alberto set Lazio to a 2-1 win over Bologna with a superb solo effort in Serie A on Saturday after the visitors had a goal disallowed.
Lazio's Ciro Immobile scored against his former club Borussia Dortmund in a 3-1 home victory marking their return to the Champions League.
Striker Fabio Quagliarella set Sampdoria on the way to a comfortable 3-0 win at home to a disappointing Lazio in Serie A on Saturday.
Inter Milan dropped their first two points of the season when they were held to a 1-1 draw by Lazio.
Atalanta captain Alejandro Gomez scored twice in an impressive 4-1 win for the Bergamo side away to top-four rivals Lazio in Serie A on Wednesday.
Roma legend Francesco Totti visited a young woman in hospital that came out from a nine-month coma after listening to his voice.
Lazio began their Serie A campaign with a convincing 2-0 win at Cagliari on Saturday.
Before you tune in to all the Serie A action on ESPN+, we break down what to watch for throughout the 2020-21 season.