Iowa StateCyclones
- 1st in Big 12
Iowa State Cyclones Schedule 2021
| Regular Season | |||||||
| DATE | OPPONENT | RESULT | W-L (CONF) | HI PASS | HI RUSH | HI REC | |
| Sun, 5 Sep | W16-10 | 1-0 (0-0) | Purdy 199 | Hall 69 | Hutchinson 88 | ||
| Sun, 12 Sep | L27-17 | 1-1 (0-0) | Purdy 138 | Hall 69 | Wilson Jr. 56 | ||
| Sun, 19 Sep | W48-3 | 2-1 (0-0) | Purdy 288 | Hall 100 | Hutchinson 133 | ||
| Sun, 26 Sep | L31-29 | 2-2 (0-1) | Purdy 263 | Hall 190 | Allen 98 | ||
| Sun, 3 Oct | W59-7 | 3-2 (1-1) | Purdy 245 | Hall 123 | Hutchinson 96 | ||
| Sun, 17 Oct | W33-20 | 4-2 (2-1) | Purdy 208 | Hall 197 | Noel 48 | ||
| Sun, 24 Oct | W24-21 | 5-2 (3-1) | Purdy 307 | Hall 70 | Hutchinson 125 | ||
| Sun, 31 Oct | L38-31 | 5-3 (3-2) | Purdy 185 | Hall 167 | Milton 68 | ||
| Sun, 7 Nov | W30-7 | 6-3 (4-2) | Purdy 252 | Hall 136 | Hutchinson 96 | ||
| Sun, 14 Nov | L41-38 | 6-4 (4-3) | Purdy 356 | Hall 51 | Hutchinson 112 | ||
| Sun, 21 Nov | L28-21 | 6-5 (4-4) | Purdy 281 | Hall 58 | Kolar 152 | ||
| Sat, 27 Nov | W48-14 | 7-5 (5-4) | Purdy 262 | Hall 242 | Hutchinson 107 | ||
| DATE | OPPONENT | RESULT | W-L (CONF) | HI PASS | HI RUSH | HI REC | |
| Cheez-It Bowl | |||||||
| Thu, 30 Dec | L20-13 | 7-6 (5-4) | Purdy 204 | Brock 42 | Noel 54 | ||