Cruz added two doubles and drove in seven runs for the reigning AL Central champion Twins, who won two of three. Maeda (1-0), a Japanese right-hander who was traded in February from the Los Angeles Dodgers, allowed two runs and struck out six in five innings.
Highly touted rookie Luis Robert hit his first career home run and right-hander Reynaldo López (0-1) and left fielder Eloy Jiménez exited early with injuries for the White Sox.
Cave hit his second career grand slam in the first. Jiménez crashed into the fence chasing the ball and left the following inning because he was light headed.
Cruz smacked a 435-foot solo shot in the fourth and added a three-run drive in the eighth for his 35th career multi-homer game. He went 7 for 13 with 10 RBI and three home runs in the series.
Marwin Gonzalez added a solo shot in the ninth for the Twins, who hit a major league-record 307 homers last season.
Robert hit a first-pitch, two-run homer off Maeda to cut the Twins' lead to 10-2 in the fifth.
López exited with right shoulder tightness after recording just two outs, throwing 38 pitches and allowing four runs. Lopez was 0-3 with a 9.60 ERA in three starts against the Twins last season.
Twins: C Willians Astudillo (COVID-19) has been cleared to join the St. Paul group after testing negative. No timeline is set for his return to the 30-man roster. He missed all of summer camp after testing positive for the virus. …RHP Jake Odorizzi (sore back) will throw a bullpen session early this week, manager Rocky Baldelli said. …CF Byron Buxton (sprained left foot) could return Tuesday in the home opener against St. Louis. …LHP Lewis Thorpe exited after a grounder hit his leg in the eighth.
White Sox: INF Yoán Moncada, who missed the start of summer camp due to COVID-19, got Sunday off for rest but is expected to play all three games in Cleveland, manager Rick Renteria said. …OF Nomar Mazara, who went on the 10-day IL Wednesday for an undisclosed reason, is "progressing well," Renteria said.
Rockies roll past Diamondbacks 10-3 despite four errors
Elias Diaz and Ryan McMahon each hit two-run homers, German Marquez threw seven impressive innings and the Colorado Rockies overcame some sloppy fielding to beat the Arizona Diamondbacks 10-3 on Saturday night.
Vazquez belts grand slam vs. Braves
Christian Vazquez belts his second career grand slam and Bobby Dalbec adds a two-run shot in the Red Sox's 8-2 win vs. the Braves.
Moncada homers as White Sox win 9-5; Cubs clinch NL Central
Yoan Moncada homered, Jose Abreu hit a three-run double and the playoff-bound Chicago White Sox beat the NL Central champion Chicago Cubs 9-5 at Guaranteed Rate Field to snap a season-high six-game losing streak Saturday.
Pirates blank Indians
Jose Osuna, Bryan Reynolds and Colin Moran all homer as the Pirates put an end to the Indians' six game winning streak.
Twins beat Reds 7-3, clinch home field in 1st round
Luis Arraez matched career highs with four hits and three RBI in his return to the lineup, and the Minnesota Twins clinched home-field advantage in the first round of the playoffs Saturday night with a 7-3 victory over the Cincinnati Reds.
Tigers use big first inning to edge Royals 4-3
Niko Goodrum and Austin Romine keyed a three-run first inning, and the Detroit Tigers edged the Kansas City Royals 4-3 on Saturday night.