No one on the Chicago White Sox seemed to mind.
Garcia homered from both sides of the plate, and Chicago pounded the Minnesota Twins 10-3 on Saturday.
Keuchel won his White Sox debut while throwing to McCann in a battery comprised of former teammates at the University of Arkansas. But the diminutive Garcia, listed at 5-foot-8 and 185 pounds, stole the show with his second career multihomer game.
"I'm not trying to hit the home run. I know what I can do," Garcia said.
Edwin Encarnacion hit a two-run drive as the White Sox bounced back nicely after losing 10-5 to the reigning AL Central champions on Friday night. McCann and Eloy Jimenez also went deep on the second day of the pandemic-delayed 60-game season.
Keuchel, who agreed to a $55.5 million, three-year contract in December, allowed two runs in 5 1/3 innings. McCann finished with three hits and two RBI.
Nice day for a pair of Razorbacks.
"James is still the same old guy," Keuchel said. "Sometimes he'll lull you to sleep with kind of the lack of emotion, but he's kind of like me where the deep down emotion is what carries him to be a great player."
Nelson Cruz connected for Minnesota, which hit a major league-record 307 homers last year. Randy Dobnak pitched four effective innings in a spot start after the Twins decided to give Rich Hill a couple more days to prepare for his debut with the team.
"I thought it was pretty good," Dobnak said. "A few I kind of let get away from me a little bit, but overall I thought the slider was doing what it was supposed to be doing."
After Dobnak (0-1) departed, the White Sox jumped all over Zack Littell. Garcia led off with a drive to right-center. With Jose Abreu aboard after a two-out single, Encarnacion and Jimenez hit consecutive homers for a 5-0 lead.
It was Encarnacion's first hit for his new team after he signed a $12 million, one-year contract with Chicago in free agency. Jimenez's drive to right hit the top of the wall and skipped over.
Littell allowed four homers in 37 innings all of last season.
"They were a very talented team last year and they've only gotten better," Twins manager Rocco Baldelli said. "You look at different parts of their lineup, they're dangerous. A lot of their guys that are young and developing are making adjustments that you can see."
Minnesota chased Keuchel (1-0) in the sixth, and Cruz hit a three-run shot off Steve Cishek. But the White Sox poured it on against the Twins' bullpen.
It also was the 11th time a White Sox player had connected from both sides of the plate in a single game.
"It was just a nice contribution across the board with everybody," manager Rick Renteria said.
The White Sox announced right-hander Carson Fulmer had been claimed off waivers by Detroit. Fulmer, who was selected by Chicago with the No. 8 pick in the 2015 amateur draft, was designated for assignment on Thursday.
Twins: CF Byron Buxton, who sprained his left foot on July 13, could make his season debut in Tuesday's home opener against St. Louis. "If it's not the home opener, it's not going to be probably much more than a day or two after that for (Buxton)," Baldelli said.
Kenta Maeda makes his Twins debut in the series finale Sunday afternoon. Maeda was acquired in a February trade that moved hard-throwing prospect Brusdar Graterol to the Los Angeles Dodgers. The Japanese right-hander went 10-8 with a 4.04 ERA in 37 appearances last season. Reynaldo Lopez pitches for the White Sox.
Jay Cohen can be reached at https://twitter.com/jcohenap
More AP MLB: https://apnews.com/MLB and https://twitter.com/AP-Sports
Rockies roll past Diamondbacks 10-3 despite four errors
Elias Diaz and Ryan McMahon each hit two-run homers, German Marquez threw seven impressive innings and the Colorado Rockies overcame some sloppy fielding to beat the Arizona Diamondbacks 10-3 on Saturday night.
Vazquez belts grand slam vs. Braves
Christian Vazquez belts his second career grand slam and Bobby Dalbec adds a two-run shot in the Red Sox's 8-2 win vs. the Braves.
Moncada homers as White Sox win 9-5; Cubs clinch NL Central
Yoan Moncada homered, Jose Abreu hit a three-run double and the playoff-bound Chicago White Sox beat the NL Central champion Chicago Cubs 9-5 at Guaranteed Rate Field to snap a season-high six-game losing streak Saturday.
Pirates blank Indians
Jose Osuna, Bryan Reynolds and Colin Moran all homer as the Pirates put an end to the Indians' six game winning streak.
Twins beat Reds 7-3, clinch home field in 1st round
Luis Arraez matched career highs with four hits and three RBI in his return to the lineup, and the Minnesota Twins clinched home-field advantage in the first round of the playoffs Saturday night with a 7-3 victory over the Cincinnati Reds.
Tigers use big first inning to edge Royals 4-3
Niko Goodrum and Austin Romine keyed a three-run first inning, and the Detroit Tigers edged the Kansas City Royals 4-3 on Saturday night.