The Argentina international is back in Paris from his home country after testing negative but has not been cleared to play.
"Lionel Messi will continue his post-COVID individual protocol in the coming days," PSG said in a statement.
Messi, 34, was one of several players to return positive results during the Ligue 1 break.
"It's always hard to pick the right team, COVID or no COVID," PSG coach Mauricio Pochettino told a news conference on Saturday.
His side lead the standings with 46 points from 19 games, 10 ahead of second-placed Marseille ahead of the club's 2,500th game.
However, PSG will not be able to count on the support of their fans, who have been banned from travelling to Lyon amid fears they might clash with the home supporters.
The banning order from the interior ministry said PSG's trips were "frequently a source of public disorder."