Manchester United defender Aaron Wan-Bissaka has withdrawn from the England squad for this month's Euro 2020 qualifiers against Bulgaria and Kosovo with a back issue, the FA said on Tuesday.
But the right-back will have to wait longer to make his debut.
"Aaron Wan-Bissaka has withdrawn from the England squad. The Manchester United right-back has returned to his club due to a back issue," the FA said in a statement.
Wan-Bissaka moved from Crystal Palace to United during the summer transfer window, and Southgate had said he was impressed with how the player handled that switch having started all four of their Premier League games this season.
He was a part of the England team at the European Under-21 Championships in the summer.
England take on Bulgaria at Wembley on Sept. 7 and Kosovo at Southampton's St Mary's stadium three days later.