| Passing Leaders | |||||||||||
| PLAYER | TEAM | RESULT | COMP | ATT | YDS | TD | INT | SACK | FUM | RAT | |
Joe Burrow |
1. Joe Burrow, QB | CIN | W 43-36 vs. TEN | 38 | 48 | 462 | 5 | 3 | 3 | 0 | 115.5 |
| 2. Deshaun Watson, QB | CLE | L 27-6 at PIT | 27 | 39 | 324 | 0 | 0 | 8 | 1 | 94.4 | |
| 3. Patrick Mahomes, QB | KC | L 28-24 at DEN | 30 | 41 | 321 | 3 | 0 | 2 | 0 | 120.1 | |
| 4. Cam Ward, QB | TEN | L 43-36 at CIN | 26 | 40 | 304 | 2 | 0 | 2 | 1 | 104.6 | |
| 5. Geno Smith, QB | NYJ | L 38-33 vs. LV | 20 | 32 | 290 | 2 | 1 | 2 | 0 | 99.7 | |
| Rushing Leaders | ||||||||||
| PLAYER | TEAM | RESULT | CAR | YDS | AVG | TD | LNG | FUM | ||
Bucky Irving |
1. Bucky Irving, RB | TB | W 16-0 vs. ATL | 27 | 170 | 6.3 | 1 | 46 | 1 | |
| 2. Jahmyr Gibbs, RB | DET | W 19-15 vs. MIN | 23 | 153 | 6.7 | 1 | 30 | 0 | ||
| 3. Tyler Allgeier, RB | ARI | W 33-30 at DAL | 11 | 147 | 13.4 | 1 | 63 | 0 | ||
| 4. Braelon Allen, RB | NYJ | L 38-33 vs. LV | 21 | 147 | 7.0 | 1 | 24 | 0 | ||
| 5. Jaylen Warren, RB | PIT | W 27-6 vs. CLE | 17 | 143 | 8.4 | 1 | 51 | 0 | ||
| Receiving Leaders | ||||||||||
| PLAYER | TEAM | RESULT | REC | YDS | AVG | TD | LNG | FUM | ||
Tee Higgins |
1. Tee Higgins, WR | CIN | W 43-36 vs. TEN | 10 | 155 | 15.5 | 2 | 32 | 0 | |
| 2. Harold Fannin Jr., TE | CLE | L 27-6 at PIT | 10 | 154 | 15.4 | 0 | 37 | 1 | ||
| 3. Adonai Mitchell, WR | NYJ | L 38-33 vs. LV | 7 | 142 | 20.3 | 1 | 47 | 0 | ||
| 4. Ja'Marr Chase, WR | CIN | W 43-36 vs. TEN | 11 | 141 | 12.8 | 1 | 30 | 0 | ||
| 5. Emmett Johnson, RB | KC | L 28-24 at DEN | 5 | 128 | 25.6 | 1 | 73 | 0 | ||
| Defensive Leaders | ||||||||||
| PLAYER | TEAM | RESULT | SOLO | AST | TOT | SACK | FF | INT | TD | |
Anthony Hill Jr. |
1. Anthony Hill Jr., LB | TEN | L 43-36 at CIN | 10 | 4 | 14 | 0.0 | 0 | 0 | 0 |
| 2. Alex Singleton, LB | DEN | W 28-24 vs. KC | 6 | 8 | 14 | 1.0 | 0 | 0 | 0 | |
| 3. Jamien Sherwood, LB | NYJ | L 38-33 vs. LV | 5 | 9 | 14 | 0.0 | 0 | 0 | 0 | |
| 4. Joshua Metellus, S | MIN | L 19-15 at DET | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |
| 5. Kendal Daniels, LB | ATL | L 16-0 at TB | 6 | 7 | 13 | 0.0 | 0 | 0 | 0 | |